• Entry into CNS is tightly regulated by highly

  2022-09-30

  

  Entry into CNS is tightly regulated by highly dynamic barriers, namely, the BBB, the blood-CSF barrier, and the arachnoid epithelium (Abbott et al., 2010; Yasuda et al., 2013). Similar barriers also exist within the CNS including the ependymal barrier as well as the cellular membrane barriers of the

• Instead our results reveal that autophagy controls the membr

  2022-09-30

  

  Instead, our results reveal that autophagy controls the membrane association of the cargo-selective SNX-BAR retromer assembly (comprised of the VPS35/29/26 trimer in association with SNX1/2 and SNX5/6), which has been demonstrated to promote GLUT1 surface recycling. Accordingly, GLUT1 localization i

• In the present study we tested glucosidase and

  2022-09-30

  

  In the present study, we tested α-glucosidase and tyrosinase inhibitory effects of the methanol extract from lower stems and PRIMA-1 of Q. coccifera (1) as well as the isolated compounds [lyoniresinol-9-O-β-xylopyranoside (2) and lyoniresinol-9-O-β-glucopyranoside (3), cocciferoside (4), (-)-8-chlor

• Previous attempts to minimize the contribution of the compen

  2022-09-30

  

  Previous attempts to minimize the contribution of the compensatory changes due to chronic loss of Gcgr, have used temporally-controlled reduction of glucagon levels by alpha-cell ablation, glucagon immunoneutralization, and the use of small molecule or antibody glucagon receptor antagonists [10], [3

• The findings in this study may represent an

  2022-09-30

  

  The findings in this study may represent an example of a more general phenomenon, namely that the exquisite specificity of the G protein-coupled receptors that mediate the physiological actions of the Immunology Inflammation Compound Library receptor family hormones in mammals may have arisen relati

• br Materials and methods br Results br Discussion Employment

  2022-09-30

  

  Materials and methods Results Discussion Employment of GIPR signaling, specifically the direction of this manipulation, as a strategy to improve body weight remains a contentious subject of intense scientific investigation [22], [32], [33]. Despite the physiological benefits of GIP on EHop-

• br G protein coupled receptor GPR also

  2022-09-30

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty A 205804 receptor receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented that GPR40 ago

• WT associated protein WTAP a nuclear protein is first identi

  2022-09-29

  

  WT1 associated protein (WTAP), a nuclear protein, is first identified by Little [6] who noticed its specific interaction with WT1. Besides several essential physiological processes, such as mRNA stabilization [7], eye development [8], m6A methylation [9], mRNA alternative splicing [10] and Fumagilli

• protease activated receptor It is well known that TLR induce

  2022-09-29

  

  It is well known that TLR4-induced inflammation is associated with behavioural alterations including fever, hypolocomotion, altered appetite, anxiety and anhedonia (Dantzer, 2006, Dantzer et al., 2008). The current data demonstrate that while PF3845 potently attenuates TLR4-induced cytokines in the

• The exocytosis promotion is triggered upon the

  2022-09-29

  

  The lxr agonists promotion is triggered upon the binding of Ca2+ to the C2 domains of two key protein groups, i.e. complexin and certain synaptogamins (Lai et al., 2017; Rizo and Xu, 2015). The first step of the vesicle fusion is the priming of the secretory vesicles, involved at the switching from

• Our biological data also showed that in presence of LEDGF

  2022-09-29

  

  Our biological data also showed that, in presence of LEDGF/p75, R or S of glycerol T instead of T4, T8 or T12 loop in the T30695-GQ differently affected the integration activity of the enzyme (Table 2), whereas the position but not the chirality of glycerol T affected the inhibitory efficiency of T3

• HOs can be found in both plants and

  2022-09-29

  

  HOs can be found in both plants and animals and they are evolutionarily conserved proteins [8]. There are two HO isoenzymes: inducible heme oxygenase-1 (HO-1) and constitutive heme oxygenase-2 (HO-2) encoded by different genes [9,10]. Biosynthesis of a stress-inducible HO-1 can be triggered by a var

• Recently a G protein coupled

  2022-09-28

  

  Recently, a G-protein-coupled receptor, GPR109a, was identified as a molecular target for niacin. Following this breakthrough, our group initiated a drug discovery program focused on the development of a high affinity ‘flush-free’ niacin-like agonist. Previously, we reported on the identification of

• Some years ago it has been described

  2022-09-28

  

  Some years ago, it has been described that CD45RA+ CD62L+ naïve CD4+ T Olanzapine can be further differentiated into two distinct subpopulations by analysing their surface expression of CD31(Kimmig et al., 2002a; Kohler and Thiel, 2009; Kohler et al., 2005b). CD31+ thymicnaive CD4+ T cells are enri

• Some years ago it has been described

  2022-09-28

  

  Some years ago, it has been described that CD45RA+ CD62L+ naïve CD4+ T IAA-94 can be further differentiated into two distinct subpopulations by analysing their surface expression of CD31(Kimmig et al., 2002a; Kohler and Thiel, 2009; Kohler et al., 2005b). CD31+ thymicnaive CD4+ T cells are enriched

14469 records 339/965 page Previous Next First page 上5页 336337338339340 下5页 Last page