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Evaluating the plausibility of this selective scenario is
2021-10-18
Evaluating the plausibility of this selective scenario is challenging because of the uncertainties concerning the biological role of calpain-10 and the significance of its variants with regard to gene function and disease susceptibility. However, from a strictly evolutionary standpoint, our findings
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br Conclusion br Introduction The intracellularly generated
2021-10-18
Conclusion Introduction The intracellularly generated metabolite methylglyoxal (MG, 2-oxopropanal) acts as a potent electrophile causing irreparable cellular damage if allowed to build to cytotoxic concentrations [1], [2], [3], [4], [5], [6]. The glyoxalase (Glx) system is an enzyme couple cri
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Being a facultative intracellular pathogen C pseudotuberculo
2021-10-18
Being a facultative intracellular pathogen, C. pseudotuberculosis is exposed to oxygen and nitrogen species (ROS and RNS, respectively) reactive environment within macrophages (Nathan and Shiloh, 2000), apart from species endogenously generated by metabolic processes. These molecules interact with D
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Finally the results in this article indicate that atomistic
2021-10-18
Finally, the results in this article indicate that atomistic MD in conjunction with computational electrophysiology and ion-permeation simulations provide a useful tool for the functional annotation of ion-channel structures. In particular, they exemplify how MD simulations in native lipid membranes
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To maintain low Glu concentrations in the synaptic cleft
2021-10-18
To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino streptozocin is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and
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Because sleep and metabolism are intimately linked the autho
2021-10-18
Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The integrin inhibitor allocation hypothesis of sleep posits that organisms temporally parti
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Glutamate aspartate transporters or excitatory amino acid
2021-10-18
Glutamate-aspartate transporters or excitatory amino enzyme substrate transporters (EAATs) are essential for the maintenance of glutamate homeostasis. EAATs are widely distributed in central neurons and glial cells (Danbolt, 2001, Martinez-Lozada et al., 2011). They are driven by Na + and K+ gradie
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br Experimental br Results br Discussion The use of
2021-10-18
Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,
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Superoxide Dismutase (SOD) Activity Assay Kit australia Take
2021-10-18
Taken together, our results show that, at least in the in vitro cell line model, methylation within the proximal promoter region of GHSR is an important determinant of its expression; however, to determine whether this represents a physiologically and or pathophysiologically relevant event, further
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br Materials and methods br
2021-10-18
Materials and methods Results Discussion Ghrelin is required for maintenance of glucose homeostasis under fasting conditions, and GHSR-null mice have low fasting blood glucose levels [5], [9]. In this study, we found that restoration of GHSR in nodose ganglion neurons rescued low fasting bl
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We sought to deduce the role of
2021-10-16
We sought to deduce the role of membrane lipid determinants on endo- and exocytosis by applying a combination of metabolic (lipid) engineering approaches and biophysical methods, e.g. classical optical imaging technologies and high-resolution time-resolved patch-clamp/capacitance measurements. The
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Recently the toxicity of TBT was demonstrated at the
2021-10-16
Recently, the toxicity of TBT was demonstrated at the vascular level in animal models (Nath, 2008), and the results obtained so far suggest that TBT may be a potential risk factor for cardiovascular diseases. TBT is capable to alter the coronary vascular reactivity to estradiol (dos Santos et al., 2
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Hypoxia inducible factors HIFs including HIF HIF HIF and HIF
2021-10-16
Hypoxia-inducible factors (HIFs), including HIF-1α, HIF-1β, HIF-2α and HIF-3α, are important endogenous signaling proteins that contribute to the cellular response to hypoxia. Among these proteins, HIF-1α is involved in many pathophysiological processes, including inflammation, tumor growth and meta
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The increased levels of proinflammatory cytokines in BALF ar
2021-10-16
The increased levels of proinflammatory cytokines in BALF are noted during ALI/ARDS, and the persistent elevation of these mediators may exaggerate systemic or focal inflammatory reaction with a worse outcome. These cytokines, particularly TNF-α and IL-6, play essential roles in ALI [16,17]. The ove
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As a possible back up
2021-10-16
As a possible back-up to Sch 503034 (), we explored inhibitors that contained alternative electrophiles to ketoamides. Boronic acids have been extensively investigated as possible electrophiles that could react with nucleophilic serine in the context of developing inhibitors of thrombin receptor and
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