• It is well established that a number of

  2020-11-20

  

  It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju

• br Disclosure statement br Acknowledgements

  2020-11-20

  

  Disclosure statement Acknowledgements This research was supported by grants from the National Institutes of Health, NS046400 and AG022971 (SD), and a fellowship from the Korea Research Foundation, KRF-2007-357-E00016 (YTK). The authors thank Dr. Barbara Crain for assistance with the immunologi

• br Materials and methods BAECs CAB

  2020-11-20

  

  Materials and methods BAECs (CAB30405, Toyobo Life Science, Osaka, Japan) were cultured in Dulbecco’s Modified Eagle Medium supplemented with 10% Fetal Bovine Serum (04-001-1A-US, Biological Industries, Kibbutz Beit Haemek, Israel) and 1% antibiotic-antifungal agent containing 10,000-μg/mL penici

• Though the physiological roles of microglia derived elastase

  2020-11-20

  

  Though the physiological roles of microglia-derived elastases in the CNS are not well understood, their involvement in the metabolism of cholecystokinin [41] and in the processing of plasminogen to produce a low molecular weight plasminogen that enhances neurite outgrowth has been reported [38]. Exp

• Pursuant to our in vitro data that neutrophilic

  2020-11-20

  

  Pursuant to our in vitro data that neutrophilic elastase activated the elastase-dependent oncolytic virus, we initially hypothesized that tumor-infiltrating neutrophils could be the source for elastase in tumor tissue. However, we did not detect neutrophils in the PANC-1 tumor tissue where we observ

• Environmental cues such as microbial dietary

  2020-11-20

  

  Environmental cues, such as microbial, dietary, and neuronal signals, regulate the differentiation and function of ILC3s. However, the identities of any additional cues and the receptors that detect them remain unknown. An important class of proteins enabling cells to sense extracellular cues are G-

• Ubiquitination can occur on a single monoubiquitination or s

  2020-11-20

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

• The fact that the mean tumor size

  2020-11-20

  

  The fact that the mean tumor size of the E1202-654 + α-GalCer group was much smaller than that of the α-GalCer inoculated group in both protocols indicates that immunization with E1202-654 plus α-GalCer, which induces a strong CD8+ T cell E1 antigen-specific immune response, is involved in the elimi

• The present work shows that normal climatic conditions are

  2020-11-20

  

  The present work shows that normal climatic conditions are not critical for the long time survival of DNA in untreated blood stains. This information may be useful for laboratories who wish to store reference blood samples in a simple way, while saving the costs of commercial substrates that are tre

• Electron transport via DHODH activity

  2020-11-20

  

  Electron transport via DHODH activity will allow the generation of mitochondrial ROS without the consumption of α-ketoglutarate or NADH. Glutamine-dependent flux through the TCA cycle and oxidative phosphorylation can also enable generation of mitochondrial ROS (Weinberg et al., 2010). The latter pr

• In this review focusing on biocatalyst

  2020-11-19

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic Monastrol receptor oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation

• br Materials and methods br Author contributions

  2020-11-19

  

  Materials and methods Author contributions Acknowledgements Supported by grants from the Zhejiang Provincial Natural Science Foundation (LY16H030016, LY17H030012), and the Zhejiang Science and Technology Public Welfare Project (2015C33279), Anesthesiology Center in North of Zhejiang Provinc

• N fowleri enters the host through the

  2020-11-19

  

  N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the 5-(N,N-dimethyl)-Amiloride hydrochloride australia where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immun

• N methyl d aspartate NMDA

  2020-11-19

  

  N-methyl-d-aspartate (NMDA) receptor antagonists, such as MK-801 and phencyclidine, induce cognitive dysfunction in both mice and humans [18]. In addition, antipsychotic drugs ameliorate MK-801-induced cognitive dysfunction; therefore, the acute application of MK-801 can be used as an animal model o

• It is of interest to point out that curcumin

  2020-11-19

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general Ranolazine of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 deficiency

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