• GSA 10 synthesis br Acknowledgments br Introduction Social s

  2020-07-30

  

  Acknowledgments Introduction Social software applications – such as wikis, weblogs, and social networking sites (SNS) – have recently attracted organizational researchers’ attention (e.g., Kane and Fichman, 2009, Kane et al., 2014a). The impressive growth of public social web sites, like Faceb

• br The oxygenation level has an impact on

  2020-07-30

  

  The oxygenation level has an impact on various aspects of skin physiology, but mechanisms of these effects, including the role of hypoxia in epidermal differentiation, are still poorly understood. The main components of the hypoxia pathway are short-lived transcription factor HIF1a (stabilized by

• As hydrophobic residues make up almost of all

  2020-07-29

  

  As hydrophobic residues make up almost 40% of all the residues in the DGAT1 proteins [74] (Fig. 2a and c), they presumably play an important role in facilitating the reaction. While it is clear that alterations within the Sit1 motif, especially of the critical tyrosine (Y), alter binding to oleoyl-C

• The small molecule d mannuronic acid M

  2020-07-29

  

  The small molecule β-d-mannuronic CAY10499 (M2000), patented (DE-102016113018.4), has been tested as an anti-inflammatory and a novel immunosuppressive agent in various experimental models such as animal models of immune complex glomerulonephritis, nephrotic syndrome, multiple sclerosis and rheumat

• The successful application of this hierarchical model depend

  2020-07-29

  

  The successful application of this hierarchical model depends on how well it is solved in handling realistic complications. A significant amount of effort have been devoted to solving bilevel mathematical programming and many efficient algorithms have been proposed. To date a few algorithms exist to

• Induction of DNA double stranded breaks DSBs

  2020-07-28

  

  Induction of DNA double stranded breaks (DSBs) by radiation is considered an effective approach for the treatment of cancer (Jeggo and Lobrich, 2007, McKinnon and Caldecott, 2007). Both radiation and a wide range of anticancer agents act by the induction of DSB in cancer cells, thereby causing cell

• br Conclusion Unlike the dogma described above our recent

  2020-07-28

  

  Conclusion Unlike the dogma described above, our recent studies strongly suggest that DGK isozymes utilize not only PI turnover-derived DG species but also various DG species derived from pathways independent of PI turnover. Different DG species supplied form distinct pathways may be utilized by

• br Materials and methods br Results br

  2020-07-28

  

  Materials and methods Results Discussion As the critical enzyme for de novo pyrimidine biosynthesis, hDHODH is considered as a promising target for the development of anti-proliferative, anti-inflammatory and immunosuppressive drugs since rapid cell proliferation often relays on de novo syn

• Introduction Psoralea corylifolia L Leguminosae

  2020-07-28

  

  Introduction Psoralea corylifolia L. (Leguminosae) is a well-known traditional Chinese medicine, and it has been widely used for the treatment of various diseases like bronchial asthma, leucopenia, vitiligo and psoriasis in East Asian countries (Zhang et al., 1990). Previous studies have reported t

• It is outside the scope of this review

  2020-07-28

  

  It is outside the scope of this review to discuss all members of the Ca2+-signaling toolkit involved in the modulation of autophagy and we will focus here only on those that are necessary for the topic of this review (see Section 5), i.e. CaM, the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) a

• br Materials and methods br Results

  2020-07-28

  

  Materials and methods Results Discussion Methylation is the main epigenetic modification in humans and changes in methylation patterns play important roles in tumorigenesis and metastasis. The MS-PCR technique enables precise mapping of methylation patterns in CpG islands of genomic DNA. Th

• Using a probe substrate to determine

  2020-07-28

  

  Using a probe substrate to determine the metabolic activities of cytochrome P450 is used widely in present drug–drug interaction studies. In this study, the effects of morroniside on the activity, mRNA and protein expression of CYP3A were investigated ex vivo by using rat liver microsomes. The effec

• Corticotropin releasing factor CRF is strongly implicated in

  2020-07-28

  

  Corticotropin-releasing factor (CRF) is strongly implicated in negative affect and anxiety states (Radulovic et al., 1999, Takahashi, 2001, Bale and Vale, 2004, Bale, 2005, Lukkes et al., 2009b). Activation of the CRF2 receptors within the serotonergic cell body region, the dorsal raphe nucleus (dRN

• Merimepodib The results from this short term laboratory stud

  2020-07-28

  

  The results from this short-term laboratory study corroborate the use of T-ChE and Es-ChE activity in gills and digestive gland (albeit, with higher control variance) of Saccostrea sp. as sensitive biomarkers of xenobiotic exposure. We show that a common organophosphate pesticide, chlorpyrifos, caus

• The biological importance of the signaling pathway s

  2020-07-28

  

  The biological importance of the signaling pathway(s) elicited by CHK is not fully comprehended. Ras, identified here as a signal transducer acting downstream to CHK (Fig. 4C and D), is a potent oncogene and mutated forms are found in approximately 30% of all human cancers [41]. In contrast to its g

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